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Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents.

Previously, mouse NIH 3T3 cells were stably transfected with human DNA polymerase beta (beta-pol) cDNA in the antisense orientation and under the control of a metallothionein promoter [Zmudzka, B.Z. and Wilson, S.H. (1990) Som. Cell Mol. Gen., 16, 311-320]. To assess the feasibility of enhancing the...

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Main Authors: Horton, J K, Srivastava, D K, Zmudzka, B Z, Wilson, S H
Format: Artigo
Jezik:Inglês
Izdano: 1995
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC307295/
https://ncbi.nlm.nih.gov/pubmed/7479021
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