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Mismatch repair proteins, MSH2, MLH1 and EXO1 are important for class switch recombination events occurring in B cells that lack non-homologous end joining
In the absence of core nonhomologous end-joining (NHEJ) factors, antibody gene class switch recombination (CSR) uses an alternative-end joining (A-EJ) pathway to recombine switch (S) region DNA breaks. Previous reports showing decreased S-junction microhomologies in MSH2-deficient mice, and an exonu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072809/ https://ncbi.nlm.nih.gov/pubmed/21242524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003104 |
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