The Y238X Stop Codon Polymorphism in the Human β-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis

Background. Dectin-1 is the major receptor for fungal β-glucans on myeloid cells. We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients. Methods. Association of Dect...

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Main Authors: Chai, Louis Y.A., de Boer, Mark G. J., van der Velden, Walter J. F. M., Plantinga, Theo S., van Spriel, Annemiek B., Jacobs, Cor, Halkes, Constantijn J. M., Vonk, Alieke G., Blijlevens, Nicole M., van Dissel, Jaap T., Donnelly, Peter J., Kullberg, Bart-Jan, Maertens, Johan, Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072717/
https://ncbi.nlm.nih.gov/pubmed/21242599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq102
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