Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation

Although glucocorticoid (GC) is widely used for treating hematopoietic malignancies including adult T-cell leukemia (ATL), the mechanism by which leukemic cells become resistant to GC in the clinical course remains unclear. Using a series of T-cell lines infected with human T lymphotropic virus type...

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Autors principals: Chen, Z, Lopez-Ramos, D A, Yoshihara, E, Maeda, Y, Masutani, H, Sugie, K, Maeda, M, Yodoi, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072512/
https://ncbi.nlm.nih.gov/pubmed/21151022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.286
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