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Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity
Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060604/ https://ncbi.nlm.nih.gov/pubmed/21119640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1127 |
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