Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramat...

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Bibliografiske detaljer
Main Authors: Yoshihara, Eiji, Fujimoto, Shimpei, Inagaki, Nobuya, Okawa, Katsuya, Masaki, So, Yodoi, Junji, Masutani, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060604/
https://ncbi.nlm.nih.gov/pubmed/21119640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1127
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