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Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication

We performed experiments to determine the effect of PKR activation on respiratory syncytial virus (RSV) replication. We first determined that RSV infection activates PKR which induces the phosphorylation of eIF2α, resulting in the formation of host stress granules. We used RNA interference to decrea...

詳細記述

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書誌詳細
主要な著者: Lindquist, Michael E., Mainou, Bernardo A., Dermody, Terence S., Crowe, James E.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Inc. 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072468/
https://ncbi.nlm.nih.gov/pubmed/21377708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.02.009
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