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Inhibition of amyloidogenesis by non-steroidal anti-inflammatory drugs and their hybrid nitrates
Poor blood-brain barrier penetration of non-steroidal anti-inflammatory drugs (NSAIDs) has been blamed for the failure of the selective amyloid lowering agent (SALA) R-flurbiprofen in phase 3 clinical trials for Alzheimer’s disease (AD). NO-donor NSAIDs (NO-NSAIDs) provide an alternative, gastric-sp...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072465/ https://ncbi.nlm.nih.gov/pubmed/21405086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101450p |
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