Identification of a bone marrow-derived CD8αα(+) dendritic cell-like population in inflamed autoimmune target tissue with capability of inducing T cell apoptosis

DCs play critical roles in promotion of autoimmunity or immune tolerance as potent APCs. In our anti-GBM GN model, WKY rats develop severe T cell-mediated glomerular inflammation followed by fibrosis. A DC-like cell population (CD8αα(+)CD11c(+)MHC-II(+)ED1(–)) was identified in the inflamed glomerul...

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Main Authors: Wu, Jean, Zhou, Cindy, Robertson, Julie, Weng, Connie C. Y., Meistrich, Marvin L., Tailor, Ramesh C., Lou, Ya-Huan
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2010
Teme:
Spotlight on Leading Edge Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072231/
https://ncbi.nlm.nih.gov/pubmed/20628068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0310133
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