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Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites

DNA-intercalating molecules can impair DNA replication, DNA repair, and gene transcription. We previously demonstrated that XR5944, a DNA bis-intercalator, specifically blocks binding of estrogen receptor-α (ERα) to the consensus estrogen response element (ERE). The consensus ERE sequence is AGGTCAn...

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Bibliografski detalji
Glavni autori: Sidell, Neil, Mathad, Raveendra I., Shu, Feng-jue, Zhang, Zhenjiang, Kallen, Caleb B., Yang, Danzhou
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072055/
https://ncbi.nlm.nih.gov/pubmed/21333738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2011.02.003
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