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Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites
DNA-intercalating molecules can impair DNA replication, DNA repair, and gene transcription. We previously demonstrated that XR5944, a DNA bis-intercalator, specifically blocks binding of estrogen receptor-α (ERα) to the consensus estrogen response element (ERE). The consensus ERE sequence is AGGTCAn...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072055/ https://ncbi.nlm.nih.gov/pubmed/21333738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2011.02.003 |
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