Rational Design, Synthesis and Evaluation of First Generation Inhibitors of the Giardia lamblia Fructose-1,6-biphosphate Aldolase

Inhibitors of the Giardia lamblia fructose 1,6-bisphosphate aldolase (GlFBPA), which transforms fructose 1,6-bisphosphate (FBP) to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, were designed based on 3-hydroxy-2-pyridone and 1,2-dihydroxypyridine scaffolds that position two negatively c...

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Detalhes bibliográficos
Main Authors: Li, Zhimin, Liu, Zhengang, Cho, Dae Won, Zou, Jiwen, Gong, Maozhen, Breece, Robert M., Galkin, Andrey, Li, Ling, Zhao, Hong, Maestas, Gabriel D., Tierney, David L., Herzberg, Osnat, Dunaway-Mariano, Debra, Mariano, Patrick S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071891/
https://ncbi.nlm.nih.gov/pubmed/21333622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2010.12.012
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