Novel human single chain antibody fragments that are rapidly interalizing effectively target epithelioid and sarcomatoid mesotheliomas

Human antibodies targeting all subtypes of mesothelioma could be useful to image and treat this deadly disease. Here we report tumor targeting of a novel internalizing human single chain antibody fragment (scFv) labeled with 99mTc (99mTc-M40) in murine models of mesothelioma of both epithelioid (M28...

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Main Authors: Iyer, Arun K., Lan, Xiaoli, Zhu, Xiaodong, Su, Yang, Feng, Jinjin, Zhang, Xiaoju, Gao, Dongwei, Seo, Youngho, VanBrocklin, Henry F., Broaddus, V. Courtney, Liu, Bin, He, Jiang
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071798/
https://ncbi.nlm.nih.gov/pubmed/21447742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3484
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