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Optimizing the Design of Oligonucleotides for Homology Directed Gene Targeting
BACKGROUND: Gene targeting depends on the ability of cells to use homologous recombination to integrate exogenous DNA into their own genome. A robust mechanistic model of homologous recombination is necessary to fully exploit gene targeting for therapeutic benefit. METHODOLOGY/PRINCIPAL FINDINGS: In...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3071677/ https://ncbi.nlm.nih.gov/pubmed/21483664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014795 |
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