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DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini.

In recent years two mechanisms have been proposed for the production of DNA strand breaks in cells undergoing oxidative stress: (i) DNA attack by OH radical, produced by Fenton reaction catalyzed by DNA-bound iron; and (ii) DNA attack by calcium-activated nucleases, due to the increase of cytosolic...

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Bibliografiske detaljer
Main Authors: Bertoncini, C R, Meneghini, R
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307141/
https://ncbi.nlm.nih.gov/pubmed/7659523
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