DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini.
In recent years two mechanisms have been proposed for the production of DNA strand breaks in cells undergoing oxidative stress: (i) DNA attack by OH radical, produced by Fenton reaction catalyzed by DNA-bound iron; and (ii) DNA attack by calcium-activated nucleases, due to the increase of cytosolic...
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| Publicado en: | Nucleic Acids Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1995
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7659523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.15.2995 |
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