8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells.

An oligodeoxyribonucleotide containing 8-hydroxyadenine (OH8Ade) was chemically synthesized and single- and double-stranded c-Ha-ras gene fragments with OH8Ade at the second position of codon 61 were prepared. The single-stranded ras gene fragment was used as a template for in vitro DNA synthesis wi...

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Auteurs principaux: Kamiya, H, Miura, H, Murata-Kamiya, N, Ishikawa, H, Sakaguchi, T, Inoue, H, Sasaki, T, Masutani, C, Hanaoka, F, Nishimura, S
Format: Artigo
Langue:Inglês
Publié: 1995
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC307127/
https://ncbi.nlm.nih.gov/pubmed/7659512
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