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Optimization of Circulating Biomarkers of Obatoclax-Induced Cell Death in Patients with Small Cell Lung Cancer

Small cell lung cancer (SCLC) is an aggressive disease in which, after initial sensitivity to platinum/etoposide chemotherapy, patients frequently relapse with drug-resistant disease. Deregulation of the Bcl-2 pathway is implicated in the pathogenesis of SCLC, and early phase studies of Bcl-2 inhibi...

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Autors principals: Dean, Emma J, Cummings, Jeff, Roulston, Anne, Berger, Mark, Ranson, Malcolm, Blackhall, Fiona, Dive, Caroline
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071082/
https://ncbi.nlm.nih.gov/pubmed/21472138
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