DNA-PKcs and ATM Co-Regulate DNA Double-Strand Break Repair

DNA double-strand breaks (DSBs) are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). The NHEJ/HR decision is under complex regulation and involves DNA-dependent protein kinase (DNA-PKcs). HR is elevated in DNA-PKcs null cells, but suppressed by DNA-PKcs kinase inhibito...

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Bibliografiske detaljer
Main Authors: Shrivastav, Meena, Miller, Cheryl A., De Haro, Leyma P., Durant, Stephen T., Chen, Benjamin P.C., Chen, David J., Nickoloff, Jac A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071034/
https://ncbi.nlm.nih.gov/pubmed/19535303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.05.006
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