A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia

OBJECTIVE: The objective of the study was to evaluate LINE-1 methylation as an intermediate biomarker for the effect of folate and vitamin B12 on the occurrence of higher grades of cervical intraepithelial neoplasia (CIN 2+). METHODS: Study included 376 women who tested positive for HR-HPVs and were...

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Autores principales: Piyathilake, Chandrika J., Macaluso, Maurizio, Alvarez, Ronald D., Chen, Min, Badiga, Suguna, Siddiqui, Nuzhat R, Edberg, Jeffrey C, Partridge, Edward E, Johanning, Gary L
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070926/
https://ncbi.nlm.nih.gov/pubmed/21463750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nut.2010.08.018
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