A Lower Degree of PBMC L1 Methylation in Women with Lower Folate Status May Explain the MTHFR C677T Polymorphism Associated Higher Risk of CIN in the US Post Folic Acid Fortification Era

BACKGROUND: Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+). However, it is unknown whether exposure to higher folate as a result of the...

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Detalhes bibliográficos
Main Authors: Badiga, Suguna, Johanning, Gary L., Macaluso, Maurizio, Azuero, Andres, Chambers, Michelle M., Siddiqui, Nuzhat R., Piyathilake, Chandrika J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193871/
https://ncbi.nlm.nih.gov/pubmed/25302494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110093
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