IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants....

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Bibliografiske detaljer
Main Authors: Chabaud, Martine, Lubberts, Erik, Joosten, Leo, van den Berg, Wim, Miossec, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2001
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30709/
https://ncbi.nlm.nih.gov/pubmed/11299057
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