Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions

A recently discovered enzyme system produces antibacterial hypothiocyanite (OSCN(−)) in the airway lumen by oxidizing the secreted precursor thiocyanate (SCN(−)). Airway epithelial cultures have been shown to secrete SCN(−) in a CFTR-dependent manner. Thus, reduced SCN(−) availability in the airway...

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Bibliografiske detaljer
Main Authors: Lorentzen, Daniel, Durairaj, Lakshmi, Pezzulo, Alejandro A., Nakano, Yoko, Launspach, Janice, Stoltz, David A., Zamba, Gideon, McCray, Paul B., Zabner, Joseph, Welsh, Michael J., Nauseef, William M., Bánfi, Botond
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070840/
https://ncbi.nlm.nih.gov/pubmed/21334431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.02.013
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