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Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions
A recently discovered enzyme system produces antibacterial hypothiocyanite (OSCN(−)) in the airway lumen by oxidizing the secreted precursor thiocyanate (SCN(−)). Airway epithelial cultures have been shown to secrete SCN(−) in a CFTR-dependent manner. Thus, reduced SCN(−) availability in the airway...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070840/ https://ncbi.nlm.nih.gov/pubmed/21334431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.02.013 |
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