The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule Associated Protein Tau

Target-based drug discovery for Alzheimer's disease (AD) centered on modulation of the amyloid ß peptide has met with limited success. Therefore, recent efforts have focused on targeting the microtubule-associated protein tau. Tau pathologically accumulates in more than 15 neurodegenerative dis...

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Main Authors: Jones, Jeffrey R., Lebar, Matthew D., Jinwal, Umesh K., Abisambra, Jose F., Koren, John, Blair, Laura, O'Leary, John C., Davey, Zachary, Trotter, Justin, Johnson, Amelia G., Weeber, Edwin, Eckman, Christopher B., Baker, Bill J., Dickey, Chad A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070757/
https://ncbi.nlm.nih.gov/pubmed/21141876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100572z
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