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NOVEL DELIVERY SYSTEM ENHANCES EFFICACY OF ANTIRETROVIRAL THERAPY IN ANIMAL MODEL FOR HIV-1 ENCEPHALITIS (HIVE)

Most potent anti-retroviral drugs (e.g., HIV-1 protease inhibitors) poorly penetrate the blood-brain barrier. Brain distribution can be limited by the efflux transporter, P-glycoprotein (P-gp). The ability of a novel drug delivery system (block co-polymer P85) that inhibits P-gp, to increase the eff...

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Detalhes bibliográficos
Main Authors: Spitzenberger, Timothy J., Heilman, David, Diekmann, Casey, Batrakova, Elena, Kabanov, Alexander, Gendelman, Howard E., Elmquist, William F., Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070745/
https://ncbi.nlm.nih.gov/pubmed/17063148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.jcbfm.9600414
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