Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis

Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. IDO activity is linked with immunosuppression by its ability to inhibit lymphocyte proliferation, and with neurotoxicity through the generation of quinolinic acid and other toxins. IDO i...

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Detalhes bibliográficos
Main Authors: Potula, Raghava, Poluektova, Larisa, Knipe, Bryan, Chrastil, Jesse, Heilman, David, Dou, Huanyu, Takikawa, Osamu, Munn, David H., Gendelman, Howard E., Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895260/
https://ncbi.nlm.nih.gov/pubmed/15961516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1403
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