Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

The Xolloid secreted metalloprotease, a tolloid-related protein, was found to cleave Chordin and Chordin/BMP-4 complexes at two specific sites in biochemical experiments. Xolloid mRNA blocks secondary axes caused by chordin, but not by noggin, follistatin, or dominant-negative BMP receptor, mRNA inj...

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Main Authors: Piccolo, Stefano, Agius, Eric, Lu, Bin, Goodman, Shelley, Dale, Leslie, De Robertis, Eddy M.
Format: Artigo
Jezik:Inglês
Izdano: 1997
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070600/
https://ncbi.nlm.nih.gov/pubmed/9363949
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