Mesangial Cell Integrin αvβ8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-β and Regulating PECAM-1

Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth factor-β (TGF-β). Kidney αvβ8 localizes to mesangial cells, which appose glomerular endothel...

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Autors principals: Khan, Shenaz, Lakhe-Reddy, Sujata, McCarty, Joseph H., Sorenson, Christine M., Sheibani, Nader, Reichardt, Louis F., Kim, Jane H., Wang, Bingcheng, Sedor, John R., Schelling, Jeffrey R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070557/
https://ncbi.nlm.nih.gov/pubmed/21281793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.10.031
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