Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

Microvascular pericytes and perivascular fibroblasts have recently been identified as the source of scar-producing myofibroblasts that appear after injury of the kidney. We show that cross talk between pericytes and endothelial cells concomitantly dictates development of fibrosis and loss of microva...

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Detalhes bibliográficos
Main Authors: Lin, Shuei-Liong, Chang, Fan-Chi, Schrimpf, Claudia, Chen, Yi-Ting, Wu, Ching-Fang, Wu, Vin-Cent, Chiang, Wen-Chih, Kuhnert, Frank, Kuo, Calvin J., Chen, Yung-Ming, Wu, Kwan-Dun, Tsai, Tun-Jun, Duffield, Jeremy S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070546/
https://ncbi.nlm.nih.gov/pubmed/21281822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.10.012
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