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A mammalian functional-genetic approach to characterizing cancer therapeutics
Identifying mechanisms of drug action remains a fundamental impediment to the development and effective use of chemotherapeutics. Here we describe an RNA interference (RNAi)-based strategy to characterize small-molecule function in mammalian cells. By examining the response of cells expressing short...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070540/ https://ncbi.nlm.nih.gov/pubmed/21186347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.503 |
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