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IL-12 Suppresses Vascular Endothelial Growth Factor Receptor 3 Expression on Tumor Vessels by Two Distinct IFN-γ–Dependent Mechanisms

IL-12 has been shown to be effective in enhancing antitumor responses. However, how IL-12 exerts its antiangiogenic effect is largely unknown. In this study, we elucidate this mechanism using B16 transfected to express IL-12 (B16/IL-12), a system that provides constant, local production of IL-12 wit...

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Detalhes bibliográficos
Main Authors: Sorensen, Elizabeth W., Gerber, Scott A., Frelinger, John G., Lord, Edith M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070472/
https://ncbi.nlm.nih.gov/pubmed/20061409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903210
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