RNAi mediated silencing of Nrf2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Nuclear factor erythroid-2 related factor-2 (Nrf2) is a redox-sensitive transcription factor that regulates the expression of electrophile and xenobiotic detoxification enzymes and efflux proteins, which confer cytoprotection against oxidative stress and apoptosis in normal cells. Loss of function m...

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Hlavní autoři: Singh, Anju, Boldin-Adamsky, Swetlana, Thimmulappa, Rajesh K, Rath, Srikanta K, Ashush, Hagit, Coulter, Jonathan, Blackford, Amanda, Goodman, Steven N, Bunz, Fred, Watson, Walter H, Gabrielson, Edward, Feinstein, Elena, Biswal, Shyam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070411/
https://ncbi.nlm.nih.gov/pubmed/18829555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1401
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