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Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions.

The apparent persistence length of enzymatically linearized pIBI30 plasmid DNA molecules approximately 2300 bp long, as measured by a hydrodynamic linear flow dichroism method, is markedly decreased after covalent binding of the highly tumorigenic benzo[a]pyrene metabolite 7R,8S-dihydroxy-9S,10R-epo...

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Udgivet i:Nucleic Acids Res
Principais autores: Xu, R, Mao, B, Xu, J, Li, B, Birke, S, Swenberg, C E, Geacintov, N E
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1995
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307023/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7610061/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.12.2314
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