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Characterization of the Estradiol-Binding Site Structure of Human PDIp: Indispensable Role of the Hydrogen Bond between His278 and Estradiol 3-Hydroxyl Group
Estradiol (E(2)), a female sex hormone, has important biological functions. Human pancreas-specific protein disulfide isomerase (PDIp), a protein folding catalyst, was recently found to be able to bind E(2). Here we report the characterization of its E(2)-binding site by using biochemical methods co...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070202/ https://ncbi.nlm.nih.gov/pubmed/21080683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101451g |
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