IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency associated with an increased susceptibility to herpesvirus infection and hematologic malignancy as well as a deficiency of NK cell function. It is caused by defective WAS protein (WASp). WASp facilitates filamentous actin (F-actin) branchi...

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Autori principali: Orange, Jordan S., Roy-Ghanta, Sumita, Mace, Emily M., Maru, Saumya, Rak, Gregory D., Sanborn, Keri B., Fasth, Anders, Saltzman, Rushani, Paisley, Allison, Monaco-Shawver, Linda, Banerjee, Pinaki P., Pandey, Rahul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069781/
https://ncbi.nlm.nih.gov/pubmed/21383498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44862
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