Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity.

The nuclease stability and melting temperatures (Tm) were compared for fully modified oligoribonucleotide sequences containing 2'-fluoro, 2'-O-methyl, 2'-O-propyl and 2'-O-pentyl nucleotides. Duplexes formed between 2' modified oligoribonucleotides and RNA have typical A-for...

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Autors principals: Cummins, L L, Owens, S R, Risen, L M, Lesnik, E A, Freier, S M, McGee, D, Guinosso, C J, Cook, P D
Format: Artigo
Idioma:Inglês
Publicat: 1995
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC306978/
https://ncbi.nlm.nih.gov/pubmed/7541132
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