The Anti-Hepatitis B Drug Entecavir Inhibits HIV-1 Replication and Can Select HIV-1 Variants Resistant to Antiretroviral Drugs

We show that entecavir, an FDA-approved drug used to treat chronic hepatitis B, potently inhibits HIV replication in vitro and leads to a 1 log decline in HIV RNA in vivo. Detailed analysis of two HIV-HBV co-infected patients receiving up to seven months of entecavir monotherapy demonstrated accumul...

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Main Authors: McMahon, Moira A., Jilek, Benjamin L., Brennan, Timothy P., Shen, Lin, Zhou, Yan, Wind-Rotolo, Megan, Xing, Sifei, Bhat, Shridhar, Hale, Braden, Hegarty, Robert, Chong, Curtis R., Liu, Jun O., Siliciano, Robert F., Thio, Chloe L.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069686/
https://ncbi.nlm.nih.gov/pubmed/17582071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa067710
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