Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

Flavopiridol is a protein bound, cytotoxic, cyclin-dependent kinase inhibitor. Flavopiridol given by 1-hour bolus at 50 mg/m(2) daily 3 times followed by cytosine arabinoside and mitoxantrone (FLAM) is active in adults with poor-risk acute leukemias. A pharmacologically derived “hybrid” schedule (30...

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Main Authors: Karp, Judith E., Smith, B. Douglas, Resar, Linda S., Greer, Jacqueline M., Blackford, Amanda, Zhao, Ming, Moton-Nelson, Dwella, Alino, Katrina, Levis, Mark J., Gore, Steven D., Joseph, Biju, Carraway, Hetty, McDevitt, Michael A., Bagain, Lorena, Mackey, Karen, Briel, Janet, Doyle, L. Austin, Wright, John J., Rudek, Michelle A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Clinical Trials and Observations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069672/
https://ncbi.nlm.nih.gov/pubmed/21239698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-310862
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