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Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct ligated rats and human hepatic cells
Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Despite limited benefits, ursodeoxycholic acid (UDCA) is the only FDA approved treatment for cholestatic disorders. Retinoic acid (RA) is a ligand for nuclear receptors, which modulate bile salt homeostasis. RA...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069505/ https://ncbi.nlm.nih.gov/pubmed/21274875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24047 |
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