Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

Inositol-requiring enzyme 1 (IRE1) is the most highly conserved signaling node of the unfolded protein response (UPR) and represents a potential therapeutic target for a number of diseases associated with endoplasmic reticulum stress. IRE1 activates the XBP-1 transcription factor by site-specific cl...

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Detalhes bibliográficos
Main Authors: Volkmann, Kori, Lucas, Julie L., Vuga, Danka, Wang, Xiaoping, Brumm, Duane, Stiles, Caryn, Kriebel, David, Der-Sarkissian, Ani, Krishnan, Kris, Schweitzer, Colleen, Liu, Zheng, Malyankar, Uriel M., Chiovitti, David, Canny, Marella, Durocher, Dan, Sicheri, Frank, Patterson, John B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069474/
https://ncbi.nlm.nih.gov/pubmed/21303903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199737
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