Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms

Somatic mutations of MPL exon 10, mainly involving a W515 substitution, have been described in JAK2 (V617F)-negative patients with essential thrombocythemia and primary myelofibrosis. We used direct sequencing and high-resolution melt analysis to identify mutations of MPL exon 10 in 570 patients wit...

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Bibliografiske detaljer
Main Authors: Pietra, Daniela, Brisci, Angela, Rumi, Elisa, Boggi, Sabrina, Elena, Chiara, Pietrelli, Alessandro, Bordoni, Roberta, Ferrari, Maurizio, Passamonti, Francesco, De Bellis, Gianluca, Cremonesi, Laura, Cazzola, Mario
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2011
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069239/
https://ncbi.nlm.nih.gov/pubmed/21228032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.034793
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