Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin

BACKGROUND: Pharmacological approaches to inhibit increased leukocyte adhesive interactions in sickle cell disease may represent important strategies for the prevention of vaso-occlusion in patients with this disorder. We investigated, in vitro, the adhesion molecules involved in endothelial-sickle...

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Main Authors: Canalli, Andreia A., Proença, Renata F., Franco-Penteado, Carla F., Traina, Fabiola, Sakamoto, Tatiana M., Saad, Sara T. O., Conran, Nicola, Costa, Fernando F.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069229/
https://ncbi.nlm.nih.gov/pubmed/21173096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.032912
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