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Drug screening in a zebrafish model of Duchenne muscular dystrophy

Two known zebrafish dystrophin mutants, sapje and sapje-like (sap(c/100)), represent excellent small-animal models of human muscular dystrophy. Using these dystrophin-null zebrafish, we have screened the Prestwick chemical library for small molecules that modulate the muscle phenotype in these fish....

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Hlavní autoři: Kawahara, Genri, Karpf, Jeremy A., Myers, Jennifer A., Alexander, Matthew S., Guyon, Jeffrey R., Kunkel, Louis M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069215/
https://ncbi.nlm.nih.gov/pubmed/21402949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102116108
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