Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition

The human malaria parasite Plasmodium falciparum can cause infected red blood cells (iRBC) to form rosettes with uninfected RBC, a phenotype associated with severe malaria. Rosetting is mediated by a subset of the Plasmodium falciparum membrane protein 1 (PfEMP1) variant adhesins expressed on the in...

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Main Authors: Juillerat, Alexandre, Lewit-Bentley, Anita, Guillotte, Micheline, Gangnard, Stéphane, Hessel, Audrey, Baron, Bruno, Vigan-Womas, Inès, England, Patrick, Mercereau-Puijalon, Odile, Bentley, Graham A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069207/
https://ncbi.nlm.nih.gov/pubmed/21402930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018692108
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