A Variant in a MicroRNA Complementary Site in the 3′UTR of the KIT Oncogene Increases Risk of Acral Melanoma

MicroRNAs are small ~22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3′UTRs of target gene mRNAs. Recently, mutations have been identified in both microRNAs and target genes that disrupt regulatory relationships, contribute...

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Detaylı Bibliyografya
Asıl Yazarlar: Godshalk, Sirie E., Paranjape, Trupti, Nallur, Sunitha, Speed, William, Chan, Elcie, Molinaro, Annette M., Bacchiocchi, Antonella, Hoyt, Kathleen, Tworkoski, Kathryn, Stern, David F., Sznol, Mario, Ariyan, Stephan, Lazova, Rossitza, Halaban, Ruth, Kidd, Kenneth K., Weidhaas, Joanne, Slack, Frank J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069149/
https://ncbi.nlm.nih.gov/pubmed/21119596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.536
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