A Variant in a MicroRNA Complementary Site in the 3′UTR of the KIT Oncogene Increases Risk of Acral Melanoma

MicroRNAs are small ~22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3′UTRs of target gene mRNAs. Recently, mutations have been identified in both microRNAs and target genes that disrupt regulatory relationships, contribute...

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Main Authors: Godshalk, Sirie E., Paranjape, Trupti, Nallur, Sunitha, Speed, William, Chan, Elcie, Molinaro, Annette M., Bacchiocchi, Antonella, Hoyt, Kathleen, Tworkoski, Kathryn, Stern, David F., Sznol, Mario, Ariyan, Stephan, Lazova, Rossitza, Halaban, Ruth, Kidd, Kenneth K., Weidhaas, Joanne, Slack, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069149/
https://ncbi.nlm.nih.gov/pubmed/21119596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.536
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