Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis

Although ARS-interacting multifunctional protein 2 (AIMP2, also named as MSC p38) was first found as a component for a macromolecular tRNA synthetase complex, it was recently discovered to dissociate from the complex and work as a potent tumor suppressor. Upon DNA damage, AIMP2 promotes apoptosis th...

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Main Authors: Choi, Jin Woo, Kim, Dae Gyu, Lee, Al-Eum, Kim, Hye Rim, Lee, Jin Young, Kwon, Nam Hoon, Shin, Young Kee, Hwang, Soon-Kyung, Chang, Seung-Hee, Cho, Myung-Haing, Choi, Yoon-La, Kim, Jhingook, Oh, Seung Hyun, Kim, Bora, Kim, Soo-Youl, Jeon, Hyo-Sung, Park, Jae Yong, Kang, Hyunseok Peter, Park, Bum Joon, Han, Jung Min, Kim, Sunghoon
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069106/
https://ncbi.nlm.nih.gov/pubmed/21483803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001351
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