Structuring Detergents for Extracting and Stabilizing Functional Membrane Proteins

BACKGROUND: Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason is the fact that detergents do not stabilize membrane domains as efficiently as natural lipids in membranes, often leading to a partial t...

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Detalhes bibliográficos
Main Authors: Matar-Merheb, Rima, Rhimi, Moez, Leydier, Antoine, Huché, Frédéric, Galián, Carmen, Desuzinges-Mandon, Elodie, Ficheux, Damien, Flot, David, Aghajari, Nushin, Kahn, Richard, Di Pietro, Attilio, Jault, Jean-Michel, Coleman, Anthony W., Falson, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069034/
https://ncbi.nlm.nih.gov/pubmed/21483854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018036
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