Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding intera...

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Detalhes bibliográficos
Main Authors: Ohkura, Sadayuki, Goldstone, David C., Yap, Melvyn W., Holden-Dye, Kate, Taylor, Ian A., Stoye, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068999/
https://ncbi.nlm.nih.gov/pubmed/21483490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002011
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