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Efficient and Cost Effective Population Resequencing by Pooling and In-Solution Hybridization
High-throughput sequencing of targeted genomic loci in large populations is an effective approach for evaluating the contribution of rare variants to disease risk. We evaluated the feasibility of using in-solution hybridization-based target capture on pooled DNA samples to enable cost-efficient popu...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3068187/ https://ncbi.nlm.nih.gov/pubmed/21479135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018353 |
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